Cytek Bio : Resources & References

Brochures

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Applications

Investigating COVID-19 Immune Response with the Cytek Aurora

Solutions for Infectious Disease Research

The 2020 global COVID-19 pandemic was a brutal demonstration of the devastating impacts that infectious diseases can have on human health and economic stability. In order to develop effective treatments, scientists around the world have united to evaluate and understand how the SARS-CoV-2 virus impacts the immune system and why some individuals respond more severely than others.

There are many infectious diseases, such as Ebola, HIV/AIDS, and Zika, that continue to challenge human health, with certainly more to emerge. Providing scientists with powerful, capable research solutions promote the development of new treatments to effectively battle the constantly evolving infectious disease landscape.

Technologies that Enable Immunotherapies: Part I

Advanced Immuno-Oncology Solutions

Scientists devoted to immuno-oncology (IO) are establishing new ways to target and destroy cancer cells through personalized immunotherapies. Thanks to decades of research and advances in technologies, scientists and healthcare professionals have richly documented the human adaptive and innate immune response mechanisms and are now using that information to design and administer personalized immunotherapies.

These therapies may inhibit or enhance different aspects of the immune response, depending on the action needed to hinder and destroy the life-threatening cancer cells within the human host.

High Dimensional Flow Cytometric Analysis of Rheumatoid Arthritis Patient Synovial Biopsies

Advanced Solutions for Inflammation Research

For healthy individuals, the immune system effectively identifies unwelcome microorganisms and unhealthy cells to purge them from the host. However, for individuals suffering from an inflammatory disease, the immune system is malfunctioning and attacking healthy cells and tissues. There are hundreds of inflammatory diseases, some of the more commonly known ones include asthma, lupus, rheumatoid arthritis, inflammatory bowel disease, Alzheimer’s disease, and multiple sclerosis.

Cures for many of these diseases remain undiscovered, and better treatments to make the disease manageable and extend the patient’s longevity are needed. To make these discoveries possible, scientists need access to technologically advanced, powerful research solutions.

Drug Discovery

Drug Discovery Workflows

In the pharmaceutical industry, screening drug candidates quickly at statistically powerful sample sizes enables efficient allocation of resources to new product development. There are a wide variety of drug screening assays complimenting the wide variety of different drug purposes and their mechanisms. For example, protein quantification assays are used to assess drugs designed to induce protein secretions from cells and look for protein-protein interactions; virus quantification assays are critical to assess efficacy of anti-viral drug candidates; and cytotoxicity assays evaluate cell viability after exposure to potential cancer therapeutic agents.

High-throughput technologies capable of analyzing precious patient samples with the flexibility to support a variety of assays are crucial to the everyday work of drug discovery researchers. High-throughput flow cytometers like the Cytek Aurora and Cytek Northern Lights equipped with plate loader option enable researchers to successfully conduct these drug screening assays in their search for new compounds and cell function regulators.

Check out these publications to learn more about the role of flow cytometry in drug discovery research and learn how Cytek Aurora and Cytek Northern Lights can enable drug discovery workflows in your lab.

Genomics

Decipher genetic information for each and every cell

Leveraging Sequencing Data to Design Fast Immunoprofiling Flow Cytometry Assays

In the search for differentiable cell characteristics that correlate to disease states and symptom severity, researchers collect, sequence, and compare samples from patients and healthy individuals to search for clues. While gene sequencing technologies provide rich datasets, the results can take several days to obtain and review.

Translating findings from the sequencing data to a faster technology like the full spectrum flow cytometer Cytek Aurora, where the time to result is a few hours or less, enables clinicians to get the information they need to help their patients sooner.

Learn more about Cytek Aurora.

Immunoprofiling

Deepen the understanding of how different diseases impact the cellular composition and responses of the human immune system.

Why is Immunoprofiling Important?

Quantitatively capturing a glimpse of an organism’s immune system provides useful information for many applications. This concept of immunoprofiling is vital for biomarker discovery for cancer therapeutics, understanding diseases by comparing immune phenotypes of healthy individuals with diseased, determining vaccine efficacy, and more.

Flow cytometry is a key immunoprofiling tool evidenced by its growing adoption and use by researchers. As the multiplexing capabilities of flow cytometers like the Cytek Aurora® continue to expand to 40 parameters and beyond, more complete immune system snapshots are obtained.

Number of Immunoprofiling Publications Using Flow Cytometry

Multi-Site Setup Standardization

Whether running a clinical trial to evaluate efficacy for a new drug or screening patients for disease, clinical research organizations (CROs) require controlled methods and procedures to minimize variation across sites and obtain meaningful and reliable results.

Cytek provides instruments that can be performance standardized to reduce instrument to instrument variability, enabling reproducibility of data across any site. In addition to the instrument itself, Cytek-developed software, accessories, and site services can further help CROs achieve standardization and harmonization across different sites around the world.

Webinars

Harnessing the Full Potential of Full Spectrum Cytometry

New Full Spectrum Cytometry QC & Data Analysis Tools in SpectroFlo 2.2 & FCS Express 7

Investigating COVID-19 Immune Response with the Cytek Aurora

Applying Panel Design Principles to Investigate COVID-19 Immune Response with the Cytek Aurora

Analytical Solutions for High Dimensional Spectral Flow Cytometry Data

Developing Tools for Multiplex to Single EV Analysis Pipelines

Quantitative Evaluation of Fluorochrome Combinations

Meet the cFluors Webinar January 2021

Quality Panel Design to Generate Quality Data with Case Studies

New Full Spectrum Cytometry QC & Data Analysis Tools in SpectroFlo 2.2 & FCS Express 7

Astrolabe & Cytek Webinar

Enabling and Optimizing High Quality Spectral Cytometry Analysis

Tutorials

Area Scaling Factor: What It Is, and How to Use It

Reference Control QC Tools

Bubble and Clog Detection

Boolean Gates: AND, OR, NOT

Editing Plot Properties

How to Calibrate Sample Line Depth (CalSIT) for Different Plate Types

Keeping Your Flow Cell Clean

New Preferences in SpectroFlo 2.2

Worksheet Tools

Cytek Loader Tutorial

SpectroFlo Overview Video

System Startup & QC